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. 1999 Nov 1;19(21):9298–9305. doi: 10.1523/JNEUROSCI.19-21-09298.1999

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Fig. 5. — Reduced bladder contraction in response to nicotine in β2+/+β4−/− and β2−/−β4−/− mice.A, Responses to nicotine in β2+/+β4+/+ (n = 4), β2−/−β4+/+ (n = 18), β2+/+β4−/− (n = 17), and β2−/−β4−/− (n = 12) mice are shown. Data represent the contractile response to nicotine as a percentage of that to CCH (± SEM; **p < 0.01). B,Bladder contractions in response to CCH were superimposable in β2+/+β4+/+ (●) and β2−/−β4+/+ (▴) mice and were similar in β2+/+β4−/− (■) and β2−/−β4−/− (⋄) mice. The contractility responses of both β2+/+β4−/− and β2−/−β4−/− mice were significantly different from those of β2+/+β4+/+ and β2−/−β4+/+ mice (**p < 0.01; *p < 0.05). C. Bladder contractions in response to field stimulation were similar for β2+/+β4+/+ (●) and β2−/−β4+/+ (▴) mice and for β2+/+β4−/− (■) and β2−/−β4−/− (⋄) mice. The contractility responses of β2+/+β4−/− and β2−/−β4−/− mice were significantly different from those of β2+/+β4+/+ and β2−/−β4+/+ mice (*p < 0.05).