Fig. 9.

H₂O₂ attenuates the ability of muscimol to increase intracellular Cl⁻in area CA1 pyramidal cells. The GABA_A agonist muscimol (50 μm) was applied for 10 min to the chamber containing control slices or slices previously exposed to 10 min H₂O₂. The ΔF is the change in MEQ fluorescence after 10 min of exposure of control or peroxidized slices to muscimol. The ΔF for each cell was calculated as described in Materials and Methods, except the fluorescence intensity values before muscimol addition were used for the F_b. Data are the mean ± SEM of 7–14 cells from at least three slices per condition. *p < 0.05 versus control; Student'st test.