Fig. 9.

GluR1(A) knockdown decreases GluR1(A) but not GluR2(B) immunoprotein without change in histology. A, GluR1(A) S-ODN control microinfused pup (arrow).B, After GluR1(A) hippocampal knockdown (arrow), GluR1(A) immunoreactivity was markedly reduced throughout the immature hippocampus. C, After kainate-induced status epilepticus GluR2(B), immunoreactivity was intense and unaltered throughout the hippocampus at this young age.D, GluR2(B) immunoreactivity was unchanged, suggesting that a decrease in the GluR1(A)/GluR2(B) protein was achieved.E, No seizure control; thionin-stained section after GluR2(B) knockdown without phenotypic behavior showed damage to the ventral blade of the DG (n = 4).F, GluR1(A) knockdown demonstrates intact morphology and cytoarchitecture in adjacent Nissl-stained sections from the same rat shown in B and D.