Fig. 2.

Neurochemical markers of striatal and cortical development in the absence of A_2A receptor. Representative coronal sections through corresponding levels of cortex and striatum are shown for A_2A WT (+/+, top) and KO (−/−, bottom) adult mice. Immunohistochemistry for enkephalin (Enk-IR) or dynorphin (Dyn-IR) and receptor autoradiography for NMDA receptor (³H-MK-801) in striatum and cortex were performed on brain sections as described in Materials and Methods. The characteristic striosomal pattern of dynorphin in striatum was indistinguishable between A_2A WT and KO mice (arrows).