Table 1.
Cerebrovascular and systemic physiology before, during, and after MCA occlusion-induced ischemia in A2A wild-type and knock-out mice
| Mean arterial BP (mmHg) | Cortical blood flow (%) | Heart rate (beats/min) | ||||
| Hemodynamics | A2A+/+ | A2a −/− | A2A+/+ | A2a −/− | A2A+/+ | A2a −/− |
| Before ischemia | ||||||
| 5′ | 74 ± 5 | 77 ± 4 | 100 ± 0 | 100 ± 0 | 486 ± 45 | 466 ± 38 |
| During ischemia | ||||||
| 5′ | 80 ± 10 | 78 ± 13 | 20 ± 7 | 18 ± 3 | 494 ± 101 | 483 ± 39 |
| 10′ | 79 ± 10 | 76 ± 13 | 22 ± 8 | 19 ± 4 | 529 ± 70 | 495 ± 46 |
| 20′ | 80 ± 11 | 74 ± 8 | 21 ± 6 | 19 ± 4 | 542 ± 51 | 504 ± 63 |
| 30′ | 82 ± 10 | 75 ± 8 | 22 ± 5 | 20 ± 3 | 557 ± 75 | 506 ± 64 |
| Before reperfusion | ||||||
| 5′ | 81 ± 7 | 84 ± 5 | 22 ± 7 | 20 ± 3 | 480 ± 21 | 471 ± 79 |
| During reperfusion | ||||||
| 5′ | 81 ± 5 | 83 ± 7 | 66 ± 32 | 63 ± 21 | 474 ± 24 | 473 ± 70 |
| 10′ | 86 ± 9 | 83 ± 8 | 86 ± 19 | 82 ± 20 | 476 ± 23 | 461 ± 62 |
| 20′ | 85 ± 11 | 87 ± 12 | 104 ± 20 | 96 ± 21 | 498 ± 62 | 473 ± 108 |
| 30′ | 87 ± 9 | 85 ± 13 | 110 ± 11 | 108 ± 20 | 485 ± 80 | 475 ± 108 |
| pH | PaCO2 (mmHg) | PaO2 (mmHg) | ||||
| Blood gas analysis | A2A+/+ | A2a −/− | A2A+/+ | A2a −/− | A2A+/+ | A2a −/− |
| Before ischemia | 7.34 ± 0.08 | 7.25 ± 0.05 | 40 ± 7 | 48 ± 4 | 140 ± 25 | 133 ± 26 |
| After ischemia | 7.30 ± 0.05 | 7.28 ± 0.05 | 46 ± 6 | 50 ± 7 | 166 ± 31 | 163 ± 52 |
| Body temperature (°C) | A2A+/+ | A2a −/− | ||||
| Before ischemia | 36.9 ± 0.31 | 36.9 ± 0.23 | ||||
| After ischemia | ||||||
| 1 hr | 36.9 ± 0.39 | 36.8 ± 0.30 | ||||
| 3 hr | 36.6 ± 0.32 | 36.7 ± 0.28 | ||||
| 6 hr | 36.5 ± 0.26 | 36.6 ± 0.16 | ||||
| 20 hr | 36.4 ± 0.20 | 36.4 ± 0.15 | ||||