Fig. 5.

Intravenous bolus injection of human plasminogen does not restore neuronal sensitivity of plg^−/−mice to excitotoxin. Cresyl violet (A, C) or anti-laminin immunostained (B, D) coronal brain sections through the hippocampus of PBS (A, B) or plasminogen (C,D) intravenously injected plg^−/−mice 24 hr after kainate injection. Both groups of mice are resistant to neurodegeneration and laminin degradation. CV, Cresyl violet staining; LN, anti-laminin immunostaining;arrows, kainate injection sites. Scale bar, 1 mm.