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The effect of exogenous administration of plasminogen on neuronal sensitivity to excitotoxin in plg−/− mice
| Genotype or treatment | % length of hippocampal neuronal cell layer lost after kainate injection (1.5 nmol) |
|---|---|
| Plg+/−heterozygotes (n = 5) | 86.8 ± 6.4% |
| Plg−/− mice | |
| PBS intracerebral infusion (n = 3) | 7.1 ± 3.6% |
| Plg intracerebral infusion (n = 4) | 81.9 ± 2.3% |
| PBS IV injection (n = 3) | 5.2 ± 1.5% |
| Plg IV injection (n = 4) | 7.4 ± 2.2% |
