Fig. 3.
Dose-dependent activation of the β4 and α3 promoters by Sox10. The β4/luciferase construct pX1B4FH (A) and the α3/luciferase construct pX1A3HS (B) were cotransfected with pCMVSox10 (1, 2, 4, and 8 μg) in Neuro2A cells. Luciferase values were normalized to β-galactosidase expression as driven by the SV40 promoter. Fold induction was calculated relative to the normalized luciferase activity obtained by transfecting pX1B4FH or pX1A3HS alone. Error bars represent SDs.