Fig. 6.

Simultaneous activation of group I and group II mGluRs by 1S,3R-ACPD facilitates LTD induction. A, Tetanic stimuli in the presence of 1S,3R-ACPD (100 μm, 10–15 min) induced LTD (n = 4). Mean LTD occurring 35–40 min after tetani–drug washout was −37 ± 5.7% [(n = 4, p < 0.001 vs control (Fig. 1, top right inset)]. Top tracesare averaged responses taken from time points 1 and2. A superimposed representation of the responses (1+2) is also shown. B, Bath application of 1S,3R-ACPD (100 μm) alone only transiently depressed synaptic responses, which fully recovered within 30 min (n = 4; mean percentage change of the EPSP slope 35–40 min after drug washout, 3.4 ± 4.2%).