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Time-dependent reversal of LTP by LFS.A–F, Examples in which LTP was induced at Schaffer collateral–CA1 synapses. LFS (2 Hz, 10 min) was applied at various times after LTP induction: A, 1 min after;C, 3 min after; or E, 10 min after.B, D, F, Summary of experiments similar to that shown in A,C, and E. Note that LFS erased potentiation when delivered 1 or 3 min after TS but was without effect when applied 10 min after. Calibration: 0.5 mV, 10 msec.
