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Time-dependent reversal of LTP by 5-HT1A receptor agonist buspirone application.A–D, Examples in which LTP was induced at Schaffer collateral–CA1 synapses. Buspirone (0.2 mm) was applied at various times after LTP induction: A, 1 min; orC, 10 min after. B, D, Summary of experiments similar to that shown in A andC. Note that buspirone erased potentiation when delivered 1 min after the TS but was without effect when applied 10 min after. Calibration: 0.5 mV, 10 msec.
