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The protein phosphatase 1 and 2A inhibitors prevent the LFS-induced depotentiation. A,C, Example of an experiment showing that preincubation of slice for 2–3 hr in either 1 μm okadaic acid (PP1/2A inhibitor) or 1 μm calyculin A (PP1/2A inhibitor) effectively prevented the LFS-induced depotentiation. B,D, Summary of experiments similar to that shown inA and C. Calibration: 0.5 mV, 10 msec.
