Fig. 5.

Coassembly of GluR5 and GluR6 reduces kainate receptor desensitization. A, Responses to 100 μm kainate recorded from HEK cells expressing homomeric GluR6(R) or GluR5(Q) plus GluR6(R) at a cDNA ratio of 1:1.B, Responses to 100 μm I-will recorded from HEK cells expressing homomeric GluR5(Q) or GluR5(Q) plus GluR6(R) at a cDNA ratio of 1:1. C, Desensitization, expressed as a steady-state/peak current, for homomeric GluR6(R), homomeric GluR5(Q), and GluR5(Q) plus GluR6(R) heteromers. The steady-state current amplitude was measured at 1 sec after the start of the application of the agonists. The box plots were generated by the method described in Figure 4C.