Table 1.
Mechanical and thermal responsiveness of nociceptors
| WT | NGF-OE | |
|---|---|---|
| A fibers | ||
| Median (interquartile range) von Frey threshold [mN] | 4.0 (5.2) | 5.6 (5.2) |
| % Units responding to heat | 21% (4 of 19) | 29% (15 of 51) |
| Mean ± SEM threshold for heat response [°C] | 43.6 ± 2.6 | 39.7 ± 1.2 |
| Mean ±SEM spikes per heat simulus for all units | 4.1 ± 2.7 | 4.8 ± 1.8 |
| % Units responding to cold | 10% (1 of 10) | 46% (6 of 13) |
| C fibers | ||
| Median (interquartile range) von Frey threshold [mN] | 5.6 (4.0) | 8.0 (5.6) |
| % Units responding to heat | 42% (10 of 24) | 96% (24 of 25)** |
| Mean ± SEM threshold for heat response [°C] | 39.2 ± 1.4 | 37.3 ± 0.7 |
| Mean ±SEM spikes per heat simulus for all units | 10.4 ± 3.8 | 41.1 ± 7.61-169 |
| % Units responding to cold | 33.3% (4 of 12) | 50% (5 of 10) |
**indicates that percent of fibers in NGF-OE animals is significantly different from that in controls (p< 0.01; χ2 test).
F1-169: indicates that the mean number of spikes for fibers in NGF-OE animals is significantly different from that in controls (p< 0.001; t test). All other measures do not differ significantly between wild type (WT) and NGF-OE.