Fig. 1.

Expression of Rho-family GTPase mutants affects dendritogenesis. Shown are RGCs in sections ofXenopus eye immunolabeled with anti-luciferase (A, B) or anti-myc antibodies (C–K). All cells are visualized with HRP-conjugated secondary antibodies. Photomicrographs are oriented with the PE (pigment epithelium) at the top and the lens at the bottom. A, A low-power view of a retina with a luciferase-transfected RGC and an amacrine cell (AC). Arrowheads indicate RGC and AC dendrites; arrows indicate two RGC axons exiting the eye. B, A higher power view of a luciferase-expressing RGC. Arrowheads illustrate the extensive dendritic tree. The axon of this RGC is in the next section. C–K, RGCs expressing wt, ca, and dn RhoA, Rac1, and Cdc42.Arrowheads indicate dendrites; arrowsindicate axons. Scale bar, 15 μm.