Table 1.
Summary of effects of wt-, ca-, and dn-Rho-family GTPases on RGC axons, growth cones, and dendrites
| Construct | Axons | Growth cones | Dendrites | |
|---|---|---|---|---|
| Rac1 | CA | Absent | Absent | Proliferation |
| WT | Normal | Normal | Fewer | |
| Shorter | ||||
| Some proliferation | ||||
| DN | Absent | None | Fewer | |
| Shorter | ||||
| Cdc42 | CA | Absent | Absent | Fewer |
| Shorter | ||||
| WT | Fewer in tectum/shorter | More complex | Fewer | |
| Increased errors | Shorter | |||
| Some proliferation | ||||
| DN | Normal | Less complex | Fewer | |
| Shorter | ||||
| RhoA | CA | Absent | Absent | Fewer |
| Shorter | ||||
| WT | Normal | Smaller area | Fewer | |
| Shorter | ||||
| DN | Fewer in tectum | Abnormal filopodia morphology | Normal | |
| More toward BON | ||||
| Increased errors | ||||