Fig. 5.
Effects of spatial or procedural learning on calcium-stimulated adenylyl cyclase activity. For each brain region, the graph shows the effect of increasing concentrations of Ca2+ (from 0.0 to 6.0 μm) on AC activity in membrane preparations obtained from mice trained in the procedural (open circles) or the spatial (filled circles) task or the control group (triangles). Data shown are the mean ± SEM of triplicate samples and are representative of two determinations. Behavioral training resulted in increased sensitivity of AC to calcium in all regions but parietal cortex. When observed, the magnitude of the response was greater for mice trained in the procedural task than in the spatial task, with the notable exception of the hippocampus.