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. 2019 Oct 4;12:8197–8205. doi: 10.2147/OTT.S193031

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© 2019 Wu et al.

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circZNF609 regulated proliferative and invasive capacities of GC cells through sponging miR-483-3p. (A) miR-483-3p was the potential target of circZNF609. (B and C) miR-483-3p was downregulated in GC (B) and GC cell lines (C). (D) The overexpression efficiency of miR-493-3p in SGC-7901 and BGC-823. (E and F) Dual-luciferase reporter gene assay showed the binding between circZNF609 and miR-483-3p. (F) CircZNF609 overexpression downregulated miR-483-3p overexpression in SGC-7901 and BGC-823 cells (P<0.01). (G) Abundances of circZNF609 and miR-483-3p in SGC-7901 and BGC-823 cells detected by AGO2 (RIP) assay. Ago2 was detected using IP-Western blot (up panel), and expression levels of circZNF609 and miR-483-3p were detected using qRT-PCR (down panel). (H and I) Promoted proliferative rate induced by circZNF609 overexpression was reversed after miR-483-3p overexpression in SGC-7901 (H) and BGC-823 (I) cells. (J and K) Accelerated migratory rate induced by circZNF609 overexpression was reversed after miR-483-3p overexpression in SGC-7901 (J) and BGC-823 (K) cells. *P<0.05, **P<0.01, ***P<0.001.