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. 2019 Oct 4;12:8197–8205. doi: 10.2147/OTT.S193031

Figure 4.

Figure 4

miR-483-3p-regulated proliferative and invasive capacities of GC cells through targeting CDK6. (A) CDK6 is the target of miR-483-3p. (B) CDK6 was highly expressed in GC tissues than that of paracancerous tissues (P<0.01). (C) CDK6 expression in GC cell lines (P<0.01). (E) Pearson correlation analysis showed a negative correlation between expressions of miR-483-3p and CDK6 (R=−0.635, p=0.0009). (E) Dual-luciferase reporter gene assay showed the binding between CDK6 and miR-483-3p. (F and G) The mRNA and protein levels of CDK6 in SGC-7901 (F) and BGC-823 (G) cells transfected with miR-483-3p mimics. **P<0.01; ***P<0.001.