Table 1.
Clinical and molecular characteristics of the patients.
| Characteristics | EGFL7high (n = 35) | EGFL7low (n = 36) | P |
|---|---|---|---|
| Age/years, median (range) | 54 (22–72) | 48 (18–63) | .102* |
| Age group/n (%) | .381§ | ||
| <60 years | 24 (68.6) | 28 (77.8) | |
| ≥60 years | 11 (31.4) | 8 (22.2) | |
| Gender/n (%) | .705§ | ||
| Male | 21 (60.0) | 20 (55.6) | |
| Female | 14 (40.0) | 16 (44.4) | |
| WBC/×109/L, median (range) | 29.4 (0.6–223.8) | 29.6 (0.8–202.7) | .505* |
| BM blast/%, median (range) | 67 (30–99) | 78 (34–100) | .066* |
| PB blast/%, median (range) | 49 (0–94) | 48 (0–96) | .729* |
| FAB subtypes/n (%) | |||
| M0 | 5 (14.3) | 4 (11.1) | .735§ |
| M1 | 13 (37.1) | 10 (27.8) | .399§ |
| M2 | 11 (31.4) | 7 (19.4) | .246§ |
| M3 | 0 (0.0) | 1 (2.8) | 1.000§ |
| M4 | 4 (11.4) | 9 (25.0) | .139§ |
| M5 | 0 (0.0) | 4 (11.1) | .115§ |
| M6 | 1 (2.9) | 0 (0.0) | .493§ |
| M7 | 1 (2.9) | 1 (2.8) | 1.000§ |
| Cytogenetics/n (%) | |||
| Normal | 14 (40.0) | 19 (52.8) | .280§ |
| Complex karyotype | 5 (14.3) | 6 (16.7) | .782§ |
| 8 Trisomy | 4 (11.4) | 2 (5.6) | .429§ |
| inv(16)/CBFβ-MYH11 | 4 (11.4) | 1 (2.8) | .199§ |
| 11q23/MLL | 0 (0.0) | 3 (8.3) | .239§ |
| −7/7q- | 3 (8.6) | 0 (0.0) | .115§ |
| t(15;17)/PML-RARA | 0 (0.0) | 1 (2.8) | 1.000§ |
| t(9;22)/BCR-ABL1 | 2 (5.7) | 0 (0.0) | .239§ |
| t(8;21)/RUNX1-RUNX1T1 | 1 (2.9) | 0 (0.0) | .493§ |
| Others | 2 (5.7) | 4 (11.1) | .674§ |
| Risk/n (%) | |||
| Good | 5 (14.7) | 2 (5.6) | .253§ |
| Intermediate | 16 (47.1) | 24 (60.0) | .098§ |
| Poor | 13 (38.2) | 10 (27.8) | .352§ |
| FLT3-ITD/n (%) | .832§ | ||
| Positive | 8 (22.9) | 9 (25.0) | |
| Negative | 27 (77.1) | 27 (75.0) | |
| NPM1/n (%) | .001§ | ||
| Mutation | 3 (8.6) | 15 (41.7) | |
| Wild type | 32 (91.4) | 21 (58.3) | |
| DNMT3A/n (%) | .832§ | ||
| Mutation | 8 (22.9) | 9 (25.0) | |
| Wild type | 27 (77.1) | 27 (75.0) | |
| IDH1/IDH2/n (%) | .368§ | ||
| Mutation | 10 (28.6) | 7 (19.4) | |
| Wild type | 25 (71.4) | 29 (80.6) | |
| RUNX1/n (%) | .710§ | ||
| Mutation | 3 (8.6) | 5 (13.9) | |
| Wild type | 32 (91.4) | 31 (86.1) | |
| NRAS/KRAS/n (%) | .710§ | ||
| Mutation | 4 (11.4) | 3 (8.3) | |
| Wild type | 31 (88.6) | 33 (91.7) | |
| TET2/n (%) | .614§ | ||
| Mutation | 1 (2.9) | 3 (8.3) | |
| Wild type | 34 (97.1) | 33 (91.7) | |
| TP53/n (%) | 1.000§ | ||
| Mutation | 2 (5.7) | 2 (5.6) | |
| Wild type | 33 (94.3) | 34 (94.4) | |
| MLL-PTD/n (%) | 1.000§ | ||
| Positive | 2 (5.7) | 2 (5.6) | |
| Negative | 33 (94.3) | 34 (94.4) | |
| Relapse/n (%) | .932§ | ||
| Yes | 23 (65.7) | 24 (66.7) | |
| No | 12 (34.3) | 12 (33.3) | |
| HSCT | .903§ | ||
| Haplo | 1 (2.9) | 1 (2.8) | |
| Sib allo | 14 (40.0) | 16 (44.4) | |
| MUD | 20 (57.1) | 19 (52.8) |
Abbreviations: WBC, white blood cell; BM, bone marrow; PB, peripheral blood; FAB, French American British; HSCT, hematopoietic stem cell transplantation; Haplo, haploidentical; Allo, allogeneic; MUD, matched unrelated donor.
‘*’ denotes Mann-Whitney U test; ‘§’ denotes chi-square test.