Skip to main content
. Author manuscript; available in PMC: 2019 Oct 8.
Published in final edited form as: Histopathology. 2018 Jun 1;73(2):339–344. doi: 10.1111/his.13522

Figure 1. Morphological features of solid papillary breast carcinomas resembling the tall cell variant of papillary thyroid neoplasms (BPTCs).

Figure 1

A, B) Low-power magnification of BPTC18 (A) and BPTC17 (B), displaying lobulated contours, without an overt infiltrative pattern (20x magnification, scale bar 1mm). C) Solid and papillary architecture, with evident fibrovascular cores, often with perivascular hyalinized stroma, characterized all BPTCs included in this study (BPTC14, 100x magnification, scale bar 200μm). D) Diffuse or focal follicle-like structures with colloid-like secretion were also found in all cases (BPTC15, 100x magnification, scale bar 200μm). E, F) Reverse polarity characterized by apical localization of the nuclei and enhanced cytoplasmic granularity in the basal part, was also observed in all cases (E, BPTC15; F, BPTC19; both 200x magnification, scale bar 100μm). G, H) All cases displayed grade 2 nuclear atypia, with irregularities of the nuclear membrane, nuclear grooves (G, BPTC19, 400x magnification, scale bar 50μm) and intra-nuclear pseudo-inclusions (H, BPTC19, 400x magnification, scale bar 50μm). In G and H, the highlighted nuclei with dashed lines are shown in the inset. I, J) BPTC19 diffusely expressed CK5/6 (I, 100x magnification, scale bar 200μm) and lacked a myoepithelial cell layer as shown by immunohistochemistry for smooth muscle myosin heavy chain (J, note a vessel wall as internal positive control, 100x magnification, scale bar 200μm). K, L) BPTC20 diffusely expressed CK5/6 (K, 100x magnification, scale bar 200μm) and lacked a myoepithelial cell layer as shown by immunohistochemistry for p63 (J, note the normal duct as internal positive control, 100x magnification, scale bar 200μm).