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. Author manuscript; available in PMC: 2019 Oct 8.
Published in final edited form as: Nat Struct Biol. 2003 Aug;10(8):645–651. doi: 10.1038/nsb948

Figure 1.

Figure 1

LpxC reaction and structure of TU-514. Functional groups found on substrate but not on TU-514 are in red; those unique to TU-514 are in blue. Kdo, 3-deoxy-D-manno-octulosonic acid; ACP, acyl carrier protein. Carbons of TU-514 hexose ring are numbered as with an equivalent sugar, from 1 to 6. Protons at position 1 are distinguished between axial (1a) and equatorial (1e). The α-methylene of the hydroxamate group is labeled Z. Acyl chain is numbered from 1 (carbonyl carbon) to 14 (terminal methyl). Atom s in the acyl chain are labeled (A), those from the glucose-like ring (G) and those in the hydroxamate (H).