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. Author manuscript; available in PMC: 2019 Oct 8.
Published in final edited form as: Immunometabolism. 2019 Sep 25;1:e190014. doi: 10.20900/immunometab20190014

Figure 7. mTORC1 and cMyc are required for NK1.1 plus IL2-induced NK cell effector functions.

Figure 7

(a–h) Cultured NK cells (6 days in IL15 10 ng/mL) were stimulated with a plate bound α-NK1.1 antibody (10 μg/mL) plus IL2 (20 ng/mL) ± rapamycin (20 nM) (a,d) or ±BCH (25 mM) (e–h) as indicated. Cells were analysed by flow cytometry for the production of IFNγ (a,b,e,f) or granzyme B expression (c,d,g,h). Data is representative (a,c,e,g) or mean ± SEM (b,d,f,h) of 3–6 independent experiments. Data was analyzed using a paired students t-test (* p < 0.05, ** p < 0.01, *** p < 0.001).