Skip to main content
. Author manuscript; available in PMC: 2020 Oct 1.
Published in final edited form as: Hepatology. 2019 Jun 5;70(4):1150–1167. doi: 10.1002/hep.30645

Figure 5. miR-223KO mice show higher tumor incidence and greater degree of liver fibrosis compared with WT mice after HFD feeding for one year.

Figure 5.

WT (n=21) and miR-223KO mice (n=19) were fed an HFD or CD for one year. Liver tissue samples were collected. (A) Representative photographs of liver tumors that developed in WT and miR-223KO mice are shown. Arrows indicate liver tumor. (B) Liver tumor incidence in WT and miR-223KO mice was analyzed. (C) RT-qPCR analysis of hepatic miR-223 levels after HFD feeding for one year. (D) Representative Sirius red staining and α-SMA staining of liver tissue sections are shown. (E) Quantification of fibrotic area per field. (F) RT-qPCR analyses of hepatic fibrogenesis genes. Values represent means ± SEM (n=6–21). *P< 0.05, ***P< 0.001 in comparison with WT HFD groups; #P<0.05, ##P<0.01, ###P<0.001 in comparison with WT CD groups.