Skip to main content
. Author manuscript; available in PMC: 2020 Jan 15.
Published in final edited form as: Neurobiol Aging. 2019 Mar 12;84:243.e1–243.e9. doi: 10.1016/j.neurobiolaging.2019.02.022

Table 1.

Significant (P value < 2.73×10−6) and suggestive (P value < 10−5) genes identified by stratified gene-based genome-wide analyses in ages 60–79 and ≥ 80 years using ADGC combined phase 1 and 2 samples. The top SNPs with smallest P values within genes are shown.

P value Top SNP in gene A1/A2 Age 60–79 years (younger) Age ≥ 80 years (older) Heterogeneity between the younger & older age groups
Gene Chr Frq N OR (95%CI) P value Frq N OR (95%CI) P value P value
Top genes in age 60–79 years
CR1 1 4.70×10−6 rs3818361 A/G 0.204 14867 1.21 (1.14, 1.29) 5.41×10−9 0.195 6554 1.12 (1.01, 1.23) 0.027 0.159
BIN1 2 3.67×10−8 rs6431219 T/C 0.419 14225 1.23 (1.17, 1.30) 6.06×10−14 0.408 6341 1.04 (0.96, 1.13) 0.340 6.86×10−4
OR2S2 9 8.45×10−7 rs12378268 T/C 0.320 14185 1.14 (1.08, 1.21) 5.43×10−6 0.320 6339 1.04 (0.96, 1.13) 0.363 0.0695
MS4A6A 11 8.68×10−6 rs1834550 C/T 0.389 14677 0.89 (0.84, 0.94) 1.08×10−5 0.402 6473 0.86 (0.80, 0.94) 3.38×10−4 0.587
MS4A4E 11 2.10×10−6 rs184909761 C/T 0.353 12169 0.86 (0.81, 0.92) 1.45×10−6 0.360 5340 0.85 (0.78, 0.93) 5.53×10−4 0.863
PICALM 11 8.90×10−8 rs639012 A/G 0.309 14880 0.86 (0.82, 0.91) 1.86×10−7 0.322 6552 0.98 (0.90, 1.06) 0.601 0.0132
GNPNAT1 14 4.16×10−6 rs73298734 G/A 0.108 14297 1.23 (1.13, 1.35) 1.69×10−6 0.096 6311 0.95 (0.83, 1.09) 0.455 1.29×10−3
APOE* 19 1.49×10−154 rs429358 C/T 0.248 13641 3.93 (3.65, 4.23) 4.90×10−286 0.126 6212 2.39 (2.11, 2.70) 3.90×10−43 1.41×10−11
Top genes in age ≥ 80 years
MYOZ2 4 4.13×10−6 rs4277762 T/C 0.299 14704 0.98 (0.93, 1.04) 0.476 0.306 6466 1.20 (1.10, 1.30) 2.05×10−5 8.32×10−5
APOE* 19 4.57×10−30 rs429358 C/T 0.248 13641 3.93 (3.65, 4.23) 4.90×10−286 0.126 6212 2.39 (2.11, 2.70) 3.90×10−43 1.41×10−11
ST13 22 2.82×10−6 rs6002167 T/A 0.052 14844 1.04 (0.93, 1.17) 0.502 0.051 6543 0.67 (0.55, 0.80) 2.27×10−5 8.01×10−5

Chr: chromosome; A1: effect allele; A2: non-effect allele; Frq: allele frequency of A1; N: sample size; OR: odds ratio; 95% CI: 95% confidence interval

*

APOE is shown as representatives of significant genes on chromosome 19.

The genes in bold face are shown distinct genetic effects in the younger and older groups for AD in addition to genes on chromosome 19. Their effects are significant in the younger or older group but not (P value > 0.05) in the other group. The confidence intervals of those effects in the two age groups are largely non-overlapping and significantly different based on Cochran’s Q-test for heterogeneity.