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. Author manuscript; available in PMC: 2020 Oct 7.
Published in final edited form as: Dev Cell. 2019 Aug 22;51(1):113–128.e9. doi: 10.1016/j.devcel.2019.07.022

Figure 5. Yap loss induces gradual re-differentiation of Kras mutant neoplastic ductal cells into Amylase-secreting acinar-like cells and regeneration of pancreatic parenchyma.

Figure 5.

(A) Representative images of IF staining for Amylase (Amy; red), CK19 (green), Tm (gray) and DAPI (blue) in KF and KYYF pancreata after ~1.5 months of TAM treatment. Yellow arrowheads indicate Amylase/CK19/Tm triple positive cells. Scale bars represent 500 μm (top) and 200 μm (bottom).

(B) Representative HE and IHC images of Amylase and Alcian Blue in KYYF pancreata before, after ~1.5 or >6 months of TAM treatment and KF pancreata after ~6 months of TAM. Yellow arrows mark the ductal/acinar transitional structures observed after short term TAM treatment. Scale bars represent 500 μm (top) and 25 μm (bottom).