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. Author manuscript; available in PMC: 2020 Oct 15.
Published in final edited form as: J Immunol. 2019 Sep 20;203(8):2194–2209. doi: 10.4049/jimmunol.1900230

Figure 2:

Figure 2:

BAL cell Mtb-induced canonical pathways that demonstrated a reduction in p-value of at least 2 logs following depletion of CD4+ T cells. Heat maps of -log (p-value) in unsorted BAL samples from LTBI subjects, CD4-depleted BAL cells from LTBI subjects, and unsorted BAL from Mtb-naïve subjects are presented in Figure 2A. For the 12 “signature” pathways (top), pathways significance was reduced by >2 logs in both LTBI BAL from which CD4+ T cells had been depleted and in Mtb-naïve subjects. For 22 “non-signature” pathways, decrease in -log (p-value) of >2 log was observed following CD4 depletion from LTBI BAL, but not in that of Mtb-naïve subjects. The -log p-values for 12 “signature” pathways are presented graphically in 2B. -log (p-values) for LTBI-unsorted BAL cells are presented in dark blue bars. Bars for LTBI CD4-depleted BAL cells are light blue and red bars represent -log (p-values) for unsorted BAL cells of Mtb-naïve subjects.