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. Author manuscript; available in PMC: 2020 Oct 15.
Published in final edited form as: J Immunol. 2019 Sep 20;203(8):2194–2209. doi: 10.4049/jimmunol.1900230

Figure 3:

Figure 3:

Type I IFN-associated genes identified as impacted CD4+ and CD8+ T cells on Mtb-induced BAL cell gene expression in LTBI. The figure shows 30 Type I IFN-associated upstream regulators and the degree to which the significance of their associations with the dataset were altered by depletion of CD4+ (black) or CD8+ (gray) T cells, expressed as the change in -log of p-values. As indicated, although both T-cell subset depletion impacted the significance of multiple regulators, the magnitude of this effect was far greater for CD4+ T-cells that for CD8+ cells.