FIG 1.

IL-25 signaling contributes to chronic HDM-induced lung inflammation. Cellular counts in BALFs of WT, IL-33 KO and CIKS KO mice (A); WT and IL-17RB KO mice (B) and WT and IL-17RB CD11c KO mice (C) after chronic exposure to HDM (and PBS for WT; similar to PBS for KO mice). Eosinophils (SiglecF⁺ CD11c⁺ CD11b⁺); neutrophils (Ly6G⁺, CD11b⁺, CD11c⁻); T cells (CD4⁺ TCRβ⁺). Significance indicated for HDM-treated WT vs KO mice. Data are the mean ± sem of (A) two independent experiments with n=6–7 mice per group; (B) three independent experiments with n= 7–14; (C) two independent experiments with n=5–9. * p<0.05; **p<0.01