. Author manuscript; available in PMC: 2020 Dec 30.

Published in final edited form as: Behav Brain Res. 2019 Sep 4;376:112211. doi: 10.1016/j.bbr.2019.112211

Table 2.

F values for significant main effects of drug, and significant duration by drug interactions on neurotransmitter concentrations (p < 0.05). Arrows indicate the direction of drug effects compared to the saline group. Cells containing duration names (AO or SA) indicate interactions that were only significant for one duration. Cells without duration names indicate main effects. Degrees of freedom are 1, 28 for all comparisons except for 5-HIAA in PFC and DOPAC in amygdala, which have 1, 27 and 1, 23 degrees of freedom, respectively.

Brain Region	5-HT	5-HIAA	DA	DOPAC	NE	GLU
α-PVP Compared to Saline
Amygdala		↑ 11.72		↑ 6.43
Hypothalamus	↑ SA 4.63	↑ 5.86			↑ 5.54	↑ 12.07
Hypothalamus	↑ SA 4.63	↑ AO 14.18			↑ 5.54	↑ 12.07
Striatum					↑ 5.79
Striatum					↑ SA 6.18
4MMC Compared to Saline
Amygdala	↓ 9.17
Hippocampus	↓ 7.13	↓ 10.49
Hypothalamus		↑ SA 11.43				↑ 6.44
PFC	↓ 7.33	↓ 12.60
PFC	↓ 7.33	↓ SA 6.78
Striatum	↓ 7.41	↓ 14.98	↓ 4.29		↑ 4.58
Striatum	↓ 7.41	↓ SA 7.39	↓ 4.29		↑ 4.58
Thalamus		↓ 8.80