Figure 2.

Strain comparison data reveal increased forced swim immobility after (R,S)-ketamine in unstressed mice. Immobility in this test: A, 24 hours after a single injection of (R,S)-ketamine, averaged across the last four minutes of the six minute test; B, the same animals were tested again seven days after this injection, also averaged across the last four minutes; C, 24 hour post-injection data binned in one minute intervals; D, 7 day post-injection data binned in one minute intervals. Strain-by-drug two-way ANOVAs reveal a main effect of strain at both timepoints in A and B, and a main effect of drug only at the 24 hour point. Vehicle solution is 0.9% saline. Bars and points in A-D depict mean ± standard error of mean (SEM). Significance indicators for the two-way ANOVAs (centered over each graph) are marked by *p < 0.05, **p < 0.01. See Fitzgerald et al. (2019) for detailed methodology.