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. 2019 Oct 3;12:8125–8138. doi: 10.2147/OTT.S224721

Figure 1.

Figure 1

High levels of CXCL8 are associated with poor prognosis in human glioma. (A, B) The expression levels of CXCL8 in NB and GBM obtained from the Oncomine database. The nonparametric Mann–Whitney U-test was used. (C, D) Relative CXCL8 expression levels measured by qRT-PCR in 4 NB, 34 LGG (Low-grade glioma) and 36 HGG (High-grade tissue). (E) Sixteen glioma tissues were measured for CXCL8 expression by Western blotting, including four grade I, four grade II, four grade III and four grade IV. (F, G) Representative images (F) and scores (G) of the IHC of CXCL8 expression in the paraffin-embedded different grade glioma. (H, I) Kaplan–Meier curves for DFS (H) and OS (I) of glioma patients with low vs high expression of CXCL8. The median CXCL8 expression levels were used as the cutoff value. Statistical significance was assessed using two-tailed Student’s t test (A, B, C, H and I) and one-way ANOVA followed by Dunnett’s tests for multiple comparisons (D and G). Scale bars: 50μm. *p < 0.05, **p < 0.01 and ***p < 0.001.