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. 2019 Oct 3;12:8125–8138. doi: 10.2147/OTT.S224721

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© 2019 Chen et al.

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High levels of CXCL8 promote the EMT by the JAK/STAT1/HIF-1α/Snail signal pathway in glioma cells.(A) CXCL8 knockdown decreased the protein level of p-JAK, p-STAT1, HIF-1α and Snail. Other proteins remain unchanged. (B) U-251MG and U-87MG cells transfected with CXCL8 plasmid and co-cultured with JAK/STAT signaling inhibitors were reaped, and the lysates were immuneblotted for p-JAK, Tot.JAK, p-STAT1, Tot.STAT1, HIF-1α, Snail and Slug. The histogram quantification (right panels) of p-JAK/Tot.JAK (B1), p-STAT1/Tot.STAT1 (B2), HIF-1α/β-actin (B3) and Snail/Slug (B4). Statistical significance was assessed using one-way ANOVA followed by Dunnett’s tests for multiple comparisons. *p < 0.05 and **p < 0.01.