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. 2019 Oct 8;6:194. doi: 10.1038/s41597-019-0207-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Parallel genome-wide differential expression (DE) analyses with TCGA. Rank-rank hypergeometric overlap (RRHO) heatmaps are drawn to visualize the overlap intensity between MMD- and TCGA-derived lists of genes ranked by DE between the two groups: TT vs. NT group (top row), between the two TT subgroups classified by TMi (middle row) and by known cancer type-specific classifier (bottom row). RRHO map max values, denoted as max, are stated.