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. 2019 Oct 8;9:14463. doi: 10.1038/s41598-019-51058-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Faecal concentration of lactic and acetic acid correlates with mouse survival upon P. aeruginosa regardless of faecal E. coli levels. (a) E. coli CFUs in faeces of immunocompromised mice infected with PA14 and E. coli BW25113 and kept on a protein-, fat- or carbohydrate-based diet [n = 10]. (b,c) Correlation plots and Pearson correlation coefficient (R) of faecal acetic acid (b) and lactic acid (c) concentration against the lethal time 50% (LT50) of the corresponding mice for each of the 6 conditions (3 mouse diets × 2 types of infection). (d) A combinatorial index of normalized mouse faecal acetic and lactic acid concentration correlated with LT50.