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. 2019 Oct 8;9:14408. doi: 10.1038/s41598-019-50684-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Ca²⁺ binding site mutants Doc2b^DN and Doc2b^6A enhance short-term depression in Doc2-deficient neurons. (A) Representative example traces of single EPSC from DKO neurons overexpressing Doc2b^WT or mutants. (B) Quantification of 1^st EPSC amplitude and (C) charge. (D) Quantal release or number of vesicles released during the 1^st EPSC calculated as EPSC charge divided by mEPSC charge. (E) Averaged recordings from paired-pulse stimulations and (F) ensuing paired-pulse ratio. Data are represented as mean ± SEM; Kruskall Wallis ANOVA and one way repeated ANOVA, Pairwise Post-hoc tests (*p < 0.05, **p < 0.01, ***p < 0.005). Red stars indicate outliers which were not excluded in the analysis. For each group, the number of recordings (n) and the number of independent experiments (N) are indicated as “n/N”.