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. 2019 Oct 8;10:4562. doi: 10.1038/s41467-019-12543-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Putative regulation of eRNA biogenesis in cancer. a Putative regulators of eRNAs in BRCA. Each dot represents one transcription factor (TF). Red dots denote putative master regulators significantly correlated to ≥25% of individual eRNAs. Three well-known TFs (ESR1, GATA3, and FOXA1) are highlighted. X-axis is chromosome; y-axis is percentage of eRNAs correlated to each TF. b General putative master regulators in human cancers. X-axis is symbol of putative master regulator and y-axis is cancer type. General putative master regulators involved in genomic instability are marked by red. Number in cells denotes the percentage of eRNAs regulated by each master regulator. Scale bar denotes percentage of eRNA correlated with TFs (x axis) across cancer types (y axis)