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. 2019 Oct 8;10:4562. doi: 10.1038/s41467-019-12543-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Functional characterization of NET1e in cancer. a Expression alterations of eRNAs in human cancers. Red, blue and gray, respectively, denote percentage of upregulated, downregulated and no significant expression of eRNAs in each cancer type. b Differentially expressed eRNAs in BRCA. Scale bar denotes the fold change between tumor and normal samples. c Survival curves for NET1e in BRCA (top quarter in red vs. bottom quarter in blue). d Epigenetic features and expression of NET1e and NET1 region in MCF7. e Overexpression of NET1e in MCF7 and its functional consequences. Overexpression of NET1e by CRISPR/dCas9-SAM (top left) and NET1 (top right), and cell growth assay with overexpression of NET1e in MCF7 (bottom). f Knockdown NET1e by LNA (left) and cell growth assay (right) in MCF7. g Knockdown NET1e by LNA after activation (left) and cell growth assay (right) in MCF7. h NET1e-associated drugs in GDSC and CTRP database. i Response curve of compound BEZ235 in NET1e overexpressed cells and control. j Response curve of compound Obatoclax in NET1e overexpressed cells and control. Error bars in (e), (f), (g), (i), and (j) indicate mean ± SD