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. 2019 Oct 2;12:233. doi: 10.3389/fnmol.2019.00233

Figure 1.

Figure 1

Intracerebral inoculation of brain extracts from APP23, APPPS1 and 5xFAD mice into the hippocampus of young APP-transgenic (APP-tg) host mice with genetically identical background induced seeding of Aβ pathology. In contrast, infusion of brain homogenate from a wild-type mouse into a 5xFAD tg host and vice versa failed to induce cerebral β-amyloidosis due to the lack of Aβ either in the brain extract or host animal. Fluorescence microscopy of Aβ (6E10, red) and cells (DAPI, blue). Scale bar represents 100 μm.