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. 2019 Oct 2;10:1275. doi: 10.3389/fphys.2019.01275

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Copyright © 2019 Yin, Zhao, Zheng, Wang, Li, Lu, Huang, Zhang, Chen and Ma.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Time-course changes of exosomal miR-1, miR-133a, miR-133b, miR-206, miR-208a, and miR-499 levels in plasma in response to uphill (A–F) and downhill (G–L) running (n = 12 per time point). Both uphill and downhill running shared the same rest group, and data are expressed as the fold-difference compared to the rest group. The absolute concentration of miRNAs was calculated by referring to calibration curves developed with the corresponding synthetic miRNA oligonucleotides. *denotes p < 0.05; **denotes p < 0.01; ***denotes p < 0.001.