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. 2019 Oct 2;10:680. doi: 10.3389/fendo.2019.00680

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Copyright © 2019 Alcazar and Buchwald.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Dynamic GSIS in isolated human and murine islets. Average of all experimental data collected for free murine and human islets perifused using a low (3 mM; G3, 8 min) → high (11 mM; G11, 20 min) → low (3 mM; G3, 15 min) incoming glucose stimulation (plus 10 min KCl followed by G3) as shown. Automated PERI4-02 multichannel perifusion apparatus used (samples collected every minute; 0.1 mL/min flow rate, ~100 IEQ per channel). Data are average ± SEM from multiple isolations (n = 25 and 34 total samples for murine and human, respectively).