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Concentration dependence of insulin secretion in murine and human islets. Summary of experimental data for free human (A) and murine islets (B) perifused using standard equipment and parallel stepwise incoming glucose stimulations (3 mM → 5/7/9/11/16.7/30 mM → 3 mM as indicated; plus 10 min KCl and 10 min low; corrected to ~100 IEQ per chamber; n = 3–12 per group). Averages of all data obtained in our labs for the G3 → G11 protocol are included as dashed gray lines for reference.
