Table 1.
The dysregulated expression and target genes of TIF1γ in cancer.
| Type of cancer | Subtype of cancer | TIF1γ expression | Reasons for dysregulation in cancer | Involved signaling pathways | References |
|---|---|---|---|---|---|
| Liver cancer | Hepatocellular carcinoma | Down | Hypermethylation | TGF-β signaling | (20) |
| Pancreatic cancer | Pancreatic ductal adenocarcinoma | Down | – | TGF-β signaling | (19) |
| Lung cancer | Non-small cell lung cancer | Down | SOX2 miR-429/miR-200b-3p | TGF-β signaling | (21, 35) |
| Leukemia | Chronic myelomonocytic leukemia | Down | Hypermethylation | TGF-β signaling | (93) |
| Renal carcinoma | Renal cell carcinoma | Down | miR-629 | TGF-β signaling | (25) |
| Glioblastoma | Glioblastoma multiforme | Down | – | Wnt-β-catenin | (23) |
| Colorectal cancer | – | Up | – | TGFβ/Smad4 | (79) |
| Breast cancer | – | UpDown | – | TGF-β signaling | (26) (22) |
| Cervical carcinoma | – | – | c-Abl | TGF-β signaling APC/C | (10, 36) |
TGF-β, transforming growth factor-β; SOX2, SRY-related HMG-box2; c-Abl, v-abl Abelson murine leukemia viral oncogene homolog 1; APC/C, anaphase-promoting complex/cyclosome.