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. 2019 Oct 2;10:2324. doi: 10.3389/fimmu.2019.02324

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Copyright © 2019 Wu, Fu, Yin, Guo, Wang and Ye.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A proposed model of tissue distribution and migration of LLPCs from teleosts. Anterior kidney is the bone marrow-like tissue posing the major site of B lymphocyte development where B cell progenitors and naive B cells arise. They migrate to peripheral tissue via the blood. When these B cells encounter antigen, they mature into plasmablasts or PCs in either the anterior kidney or spleen. Plasmablasts or PCs differentiate within the spleen and anterior kidney, but home to the anterior kidney, wherein PCs from all tissues compete for long-term maintenance within the survival niches in the anterior kidney.