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. 2019 Oct 8;10:4567. doi: 10.1038/s41467-019-12564-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Overall structure of the IGF1R-IGF1 complex. a 3D reconstruction of the IGF1R dimer with one IGF1 bound and the corresponding ribbon representation of this complex fitted into cryo-EM map. b The ribbon representation of IGF1R-IGF1 complex showing in two orthogonal views. c Cartoon representation of the IGF1R-IGF1 complex depicting the IGF1R dimer bound with one IGF1. The two IGF1R protomers are colored in green and blue, respectively; the IGF1 is colored in pink. The name of each domain is labeled as follows: L1 and L2 (leucine-rich repeat domains); CR (cysteine-rich domain); FnIII-1, FnIII-2 and FnIII-3 (fibronectin type III domains); α-CT (the C-terminus of the α-subunit)