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. 2019 Oct 8;9:14409. doi: 10.1038/s41598-019-50873-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Differential DNA methylation between airway epithelial cells isolated via pronase versus bronchial brush. (A) Multidimensional scale plot of samples used in the study. Black point represent bronchial brush isolated cells, red points represent pronase isolated cells. (B) P value distribution for the effect of isolation technique. Dashed line indicates the distribution expected by chance. (C) Plot of the 413,350 CpG probes used in the analysis. Red/Blue points = Benjamini-Hochberg adjusted p value < 0.05. Red = negative delta beta, Blue = positive delta beta. (D) Pyrosequencing of cg14133850; **p = 0.0014 unpaired t-test. (E) Plot of the 413,350 CpG probes used in the analysis. Grey/red/green points = Benjamini-Hochberg p value < 0.05. Grey = delta beta < 0.1, red = delta beta > 0.1, green = delta beta > 0.2. (F) Gene feature type for all analysis probes and all significant probes. HC = high-density CpG islands (CG content > 55%, Obs/Exp CpG ratio > 0.75 and length > 500 bps), IC = intermediate-density CpG islands (CG content > 50%, Obs/Exp CpG ratio > 0.48 and length > 200 bps), LC = low-density CpG regions (non-islands), ICShore = regions of intermediate-density CpG island that border HCs.