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. 2019 Oct 8;9:14409. doi: 10.1038/s41598-019-50873-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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DNA region displaying a maximum difference in DNA methylation of 40% between airway epithelial cells isolated via bronchial brush from individuals with and without asthma. (A) Methylation level of four CpGs associated with KALRN, identified by DMRcate, in bronchial brush isolated airway epithelial cells from individuals with and without asthma. (B) Methylation level of four CpGs associated with KALRN in pronase isolated HBEC cells from individuals with and without asthma. (C) Pyrosequencing of cg2344005 in cells isolated from asthmatic and non-asthmatic individuals by bronchial brush and pronase digestion. (D) Methylation level of five CpGs associated with WNT7B, identified by DMRcate, in bronchial brush isolated airway epithelial cells from individuals with and without asthma. E) Methylation level of five CpGs associated with WNT7B in pronase isolated HBEC cells from individuals with and without asthma. (F) Pyrosequencing verification of differential DNA methylation at cg22413388 between cells isolated from asthmatic and non-asthmatic individuals by pronase digestion but not bronchial brush isolation; ^*t-test p value = 0.04.