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. 2019 Jul 30;85(10):2332–2340. doi: 10.1111/bcp.14047

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© 2019 The Authors. British Journal of Clinical Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Diagnostic plots for [¹⁴C]midazolam pharmacokinetic model, using different symbols for the different treatments. (A) Observed vs population predicted [¹⁴C]midazolam concentrations. (B) Observed vs individually predicted [¹⁴C]midazolam concentrations. (C) Weighted residuals vs population predicted [¹⁴C]midazolam concentration. (D) Weighted residuals vs time. Solid lines represent the line of unity in A and B, and a value of 0 in C and D. dotted line represent ±1.96 standard deviation, representing the interval in which 95% of the conditional weighted residual (CWRES) values are expected