Table 3.
Parameter estimates of the pharmacokinetic model for IV [14C]midazolam
| Parameter | Estimate (RSE%) | Bootstrap median (2.5th to 97.5th bootstrap percentile) |
|---|---|---|
| Clearance | ||
| CL (L h−1) | 2.06 (24) | 2.23 (1.57–3.23) |
| Intercompartmental clearance | ||
| Q (L h−1) | 0.79 (44) | 0.90 (0.60–2.45) |
| Volume of distribution | ||
| V1i = V14kg * (WT/4)k1 | ||
| - V14kg (L) | 3.81 (8) | 3.75 (3.07–4.66) |
| - k1 | 1.36 (10) | 1.34 (0.68–1.68) |
| V2 (L) | 3.19 (18) | 3.30 (2.64–6.41) |
| Interindividual variability | ||
| ω2 CL | 0.73 (42) | 0.62 (0.13–1.41) |
| Residual error | ||
| Proportional error | 0.09 (24) | 0.08 (0.05–0.14) |
| Additional error | 0.08 (50) | 0.07 (0.01–0.20) |
CL = population predicted clearance; Q = intercompartmental clearance; V1i = individual predicted volume of distribution in the central compartment for individual i; V14kg = population value for volume of distribution in the central compartment at 4 kg; WT = body weight; k1 = exponent to relate body weight to volume of distribution; V2 = volume of distribution in the peripheral compartment; ω2 = variance for the interindividual variability of the parameter mentioned. The bootstrap was based on 50 resampled datasets.