Table 3. Updated hemodynamic definition based on the 6th WSPH, adapted from the original WSPH document (with prior permission).

Definition	Characteristics	Clinical groups (WHO group)
Pre-capillary PH	mPAP >20 mmHg, PAWP ≤15 mmHg, PVR ≥3 WU	1, 3, 4, 5
Isolated post-capillary PH (IpcPH)	mPAP >20 mmHg, PAWP >15 mmHg, PVR <3 WU	2 and 5
Combined pre- and post-capillary PH (CpcPH)	mPAP >20 mmHg, PAWP >15 mmHg, PVR ≥3 WU	2 and 5

Group 1: PAH; group 2: PH due to left heart disease; group 3: PH due to lung diseases and/or hypoxia; group 4: PH due to pulmonary artery obstructions; group 5: PH with unclear and/or multifactorial mechanisms. mPAP, mean pulmonary arterial pressure; PAWP, pulmonary arterial wedge pressure; PVR, pulmonary vascular resistance; WU, Wood units.